The information: There is a brand new most costly drug ever—a gene remedy that prices as a lot as a Brooklyn brownstone or a Miami mansion, and greater than the typical particular person will earn in a lifetime. Lenmeldy is a gene therapy for metachromatic leukodystrophy (MLD) and was accredited within the US on Monday. Its maker, Orchard Therapeutics, says the $4.25 million wholesale price displays the worth the therapy has for sufferers and households.

Why it issues:  MLD is a nerve dysfunction that strikes toddlers, shortly robbing them of their capacity to talk and stroll. Around half die, the others reside on in a vegetative state. But it’s extremely uncommon, affecting solely round 40 children a yr within the US. The excessive rarity of such illnesses is what’s behind the hovering price-tags of recent gene therapies, and why promoting the latest DNA therapy might be a shaky enterprise. Read the total story.

—Antonio Regalado

New York City’s plan to cease e-bike battery fires

Walk just some blocks in New York City and also you’ll possible spot an electrical bike zipping by. They have develop into more and more common lately, particularly amongst supply drivers. But the e-bike inflow has precipitated a wave of fires sparked by their batteries, a few of them lethal.

Now, town desires to struggle these fires with battery swapping. A pilot program will present a small variety of supply drivers with various choices to energy up their e-bikes, together with swapping stations that offer totally charged batteries on demand. 

Proponents say this system may lay the groundwork for a brand new mode of powering small electrical automobiles within the metropolis, one which’s handy and will scale back the chance of fires. But the street to fireplace security will possible be lengthy and winding given the sheer variety of batteries we’re integrating into our every day lives, in e-bikes and past. Read the total story.

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